Veterinary Drug Knowledge | Clinical Introduction of Three Respiratory Tract Drugs: Florfenicol, Doxycycline and Tilmicosin
Among the many prevention and treatment drugs for poultry respiratory diseases, florfenicol of amide alcohols, doxycycline of tetracyclines, and tilmicosin of macrolides, these three drugs are known as the prevention and treatment of respiratory diseases of poultry. "Three Respiratory Medicines".
In addition, there are enrofloxacin and ciprofloxacin of the floxacin class, and the compound "ligaomycin" of aminoglycosyl and lincosamide, but they all sometimes fail because of their limitations. Limited use". For example, many food animal breeding bans floxacin drugs, and the effect of ligamycin can only be guaranteed when the injection is used, and so on.
Ligaomycin
Ligaomycin is a relatively effective drug for various respiratory diseases of poultry users in recent years, but it can only be used for the treatment of systemic infections when administered orally. It is really the use of Ligaomycin (spectinomycin hydrochloride lincomycin hydrochloride soluble powder) to treat air sacculitis and refractory respiratory diseases in chickens. Only the effect of injection can be guaranteed.
1. Florfenicol mentions florfenicol products, which can be seen almost everywhere in primary veterinary pharmacies, and it is also one of the commonly used drugs in major breeding companies. However, there is no doubt that everyone knows that florfenicol alone has the most prominent clinical therapeutic value: it is used for the treatment of respiratory diseases in livestock and poultry.
As for the other application value of florfenicol products in animal breeding and production, few people have been exploring for so many years. This is a very pity, and it deserves the attention of the majority of front-line veterinarians in researching drug application and practice. What people get from professional medicines and pharmacology books is the theoretical medicine and pharmacological knowledge of florfenicol, and what the majority of grassroots veterinarians really need is: pharmacological knowledge about the clinical application of florfenicol, which is currently hindering The biggest obstacle to the correct use of florfenicol products! At present, only human medicine has professional books in this area, but there is no professional book in this area in the field of animal medicine and pharmacological application research!
Florfenicol is a third-generation amido alcohol special antibacterial and antimycoplasma drug for animals. Constant use, it is a bacteriostatic agent; high concentration use, it shows bactericidal effect. It is highly sensitive to Pasteurella hemolyticus, Pasteurella multocida, Actinobacillus pleuropneumoniae and Haemophilus that cause respiratory diseases. It is also effective against Escherichia coli, Salmonella, Proteus and Mycoplasma, and it is combined with Tilmico Star, colistin sulfate, neomycin sulfate, apramycin sulfate and doxycycline hydrochloride (ie doxycycline) will have better therapeutic effects.
2. Tilmicosin Tilmicosin has a strong antibacterial effect, excellent pharmacokinetic characteristics, and can improve the immunity of animals. In addition, the latest research shows that Tilmicosin is effective in the prevention and treatment of individual pig diseases. , Also has antiviral effect. Moreover, there is no cross-resistance with other commonly used antibiotics in clinical practice, and significant effects have been achieved in the clinical treatment of various animal diseases. Compared with tylosin, its dosage is less, the effect is long-lasting, the side effects are small, the residue in the body is low, and it is safe and non-toxic. It is an economical, safe and effective new type of antibacterial and growth-promoting veterinary drug for livestock and poultry. The state of complexity and atypical has brought new ideas and methods for clinical medication. Therefore, Tilmicosin will play a more important role in the control of livestock and poultry diseases in the future, and has broad application prospects.
Tilmicosin is a macrolide broad-spectrum anti-mycoplasma and some gram-positive antibiotics. It is currently one of the best anti-mycoplasma-specific and anti-mycoplasma drugs in clinical veterinary treatment. Due to its strong stimulating effect on the oral taste buds and gastric mucosa of livestock and poultry, the time it takes for it to be taken orally into the body by animals is prolonged, and some even exhibit varying degrees of palatability during use. This affects the effectiveness of Tilmicosin. The clinical compatibility of doxycycline, colistin sulfate and aminoglycosine has a higher and better therapeutic effect.
3. Doxycycline Doxycycline (namely doxycycline hydrochloride, the same as above) belongs to a broad-spectrum antibacterial drug of the tetracycline class. It is not only effective against Escherichia coli, Salmonella, Ornithobacter rhinotracheitis, a variety of Pasteurella, and Streptococcus It has a very good therapeutic effect, and it is also very safe for the body. In particular, its broader antibacterial and anti-mycoplasma effect, coupled with its high fat solubility, makes it have very good penetrability and permeability to poultry trachea, bronchus, alveoli, air sacs and other organs and tissues. This kind of function has the characteristics of There are very few drugs, which is why it is always widely used.
Florfenicol + Doxycycline (doxycycline)
This formula is very common, but do you know the ratio that can double the efficacy of the drug? So what is the ratio of doxycycline? The correct ratio of doxycycline and florfenicol is 2:1, everyone Be sure to dispense the medicine according to this ratio, otherwise the effect will not come out.
The specific algorithm: first calculate the dosage of doxycycline, and then divide the dosage of doxycycline by 2, and the result is the dosage of florfenicol.
Specific dosage: 1g doxycycline = about 10 kilograms of water in the case of treatment. According to this amount, the dosage will be considered, otherwise the effect will be poor. Why do we need to increase the amount here? Here, let everyone know that all tetracycline drugs should be used in an increased amount during the course of use.